Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium ntsev

Siv

Tianeptine sodium ntsev yog tricyclic antidepressant, thiab nws cov tshuaj tiv thaiv kev ntxhov siab txawv ntawm cov tshuaj tricyclic antidepressants.Nws tuaj yeem nce qhov rov ua dua ntawm 5-HT hauv qhov chaw synaptic, thiab tuaj yeem muaj txiaj ntsig ntawm kev txhim kho cov kev coj ua ntawm 5-HT neurons.Tsis muaj kev sib raug zoo rau choline lossis adrenaline receptors.Antidepressant kev ua tau zoo zoo ib yam li tricyclic, tab sis kam rau ua zoo dua tricyclic.Hauv kev sim tsiaj, nws tuaj yeem ua rau muaj kev ua haujlwm ntawm cov pyramidal hlwb hauv hippocampus thiab ua kom lawv rov qab los tom qab kev ua haujlwm inhibition.Chemicalbook nce qhov reabsorption ntawm serotonin los ntawm cov neurons hauv cerebral cortex thiab hippocampus.Kev nqus ntawm tineptine sodium hauv lub plab zom mov yog sai thiab ua tiav.Kev faib tawm sai, PPB txog li 94%.Nws tau metabolized tag nrho hauv daim siab los ntawm β-oxidation thiab N-demethylation, thiab qhov tshem tawm ntawm lub davhlau ya nyob twg T1/2 yog luv ntawm 2.5h.Ib qho me me ntawm cov tshuaj (8%) tau tawm ntawm lub raum, feem ntau nws cov metabolites los ntawm cov zis.Cov neeg mob lub raum tsis txaus tshem tawm T1 / 2 rau kev ncua 1h.