Tuam Tshoj Kub Muag CAS 7361-61-7 Xylazine cannabinoids dawb hmoov

Kev piav qhia

Xylazine yog ib qho agonist ntawm α2-adrenergic receptors (Ki = 194 nM).Nws yog ib qho analog ntawm clonidine, α2-adrenergic receptor agonist siv los txo cov ntshav siab.Xylazine yog siv rau sedation, tshuaj loog, thiab tshuaj loog hauv cov tsiaj txhu uas tsis yog tib neeg.Cov khoom no kuj muaj raws li tus qauv siv tshuaj ntsuam xyuas.
Originator Xylazine, Bayer

Siv

Antinociceptive; Alpha-2 adrenergic agonist
Siv

Xylazine yog α2 chav kawm ntawm adrenergic receptor agonist.Xylazine yog clonidine analoque uas ua rau presynaptic thiab postsynaptic receptors raws li 2-adrenergic agonist.
Kev tsim khoom

2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), npaj los ntawm 2,6- dimethylaniline nrog thiophosgene, tau ntxiv dropwise thaum lub sij hawm 15 min mus rau ib tug zoo-stirred ncua ntawm 15.0 g (0.2 mole) ntawm 3-aminopropanol-1 nyob rau hauv 100 ml ntawm ether.Lub ether pib boil.stirring nyob rau hauv reflux tau txuas ntxiv rau 30 min, thiab cov ether tau distilled tawm.Cov residue tau kho nrog 100 ml ntawm concentrated hydrochloric acid thiab boiled nyob rau hauv reflux rau 30 min.Tom qab txias, nws tau diluted nrog dej, lim dawb los ntawm impurities, thiab lub hauv paus yog precipitated los ntawm kev ntxiv ntawm concentrated sodium hydroxide tov.Thaum recrystallized los ntawm benzene-ligroin, lub resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142 ° C (yield 90% ntawm theoretical. ).
Kev kho muaj nuj nqi

Analgesic, tshuaj loog

Kev piav qhia dav dav

Xylazine yog soluble hauv methanol (50 mg / ml), yielding ntshiab, tsis muaj xim.Nws kuj yog soluble hauv dilute HCl acid thiab hauv chloroform.Xylazine yog xyaum insoluble hauv dej thiab hauv alkali daws.
Biochem/physiol Actions

Xylazine thaum siv nrog rau ketamine yog suav tias yog ib qho tshuaj loog muaj zog thiab nyab xeeb hauv cov tsiaj sim.Nws paub tias yuav ua rau lub siab tso tawm ntawm cov piam thaj, uas ua rau kom hyperglycemia.
Mechanism ntawm kev ua

Xylazine tau ua lag luam raws li nws cov ntsev hydrochloride xws li Rompun (100 mg / mL) thiab Anased (20 mg / mL) cov tshuaj txhaj tshuaj rau cov tshuaj txhaj rau hauv cov hlab ntsha rau nees thiab dev, raws li.Cov kev ua ntawm xylazine tuaj yeem thim rov qab los ntawm kev tswj hwm ntawm yohimbine, ib qho indolalkylamine alkaloid, uas thaiv cov α2-adrenoreceptors uas txhawb nqa los ntawm xylazine.
Kev ruaj ntseg Profile

Tshuaj lom los ntawm kev noj, subcutaneous, thiab intravenous txoj kev.Cov teebmeem ntawm tib neeg: kev hloov hauv lub cev muaj zog, poob hauv cov ntshav siab, miosis, pleural thickening, mem tes txo qis, somnolence.Thaum rhuab mus rau decomposition nws emissions heev fumes ntawm NOx thiab SOx